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经研究证实,干扰素(IFN)治疗慢性丙型肝炎有效,且目前应用广泛。本研究通过多变量分析α-IFN标准化治疗方案,以确定宿主因素和病毒相关因素对疗效的影响。 作者对60例慢性丙型肝炎患者进行α-IFN治疗。所有患者治疗前血清ALT持续增高(大于正常值1.5倍)6个月以上,HCVRNA阳性,组织学检查符合慢性肝炎。治疗方法:人α-IFN 6 MU,每天肌注1次,共8周,随后每周肌注2次,共16周。根据治疗后临床情况分为三组:治疗后血清ALT降至正常范围,并保持6个月以上为完全应答组;治疗期间和治疗后血清ALT持续增高1.5倍以上为无应答组;治疗期间血清
The study confirmed that interferon (IFN) treatment of chronic hepatitis C effective, and is currently widely used. In this study, multivariate analysis of α-IFN standardized treatment regimens to determine the host factors and the impact of virus-related factors on the efficacy. The author of 60 patients with chronic hepatitis C for α-IFN treatment. All patients before treatment serum ALT continued to increase (greater than 1.5 times the normal value) more than 6 months, HCVRNA positive, histological examination with chronic hepatitis. Treatment: human α-IFN 6 MU, intramuscular injection 1 times a day for a total of 8 weeks, followed by weekly intramuscular injection 2 times for a total of 16 weeks. According to the clinical situation after treatment, the patients were divided into three groups: serum ALT dropped to the normal range after treatment, and maintained for more than 6 months as the complete response group; during treatment and after treatment, serum ALT increased 1.5 times or more as no response group; serum