以前对利多卡因体内药代动力学的研究表明,连续输注明显超过常用剂量时,利多卡因的血药浓度-时间曲线图予示药物发生了蓄积,从而设想利多卡因在人体内的药代动力学可能取决于剂量。作者对给予健康志愿者超过常用剂量四倍的利多卡因的药代动力学曲线图特征进行分析。作者把7名健康成年男性志愿者随机分三组,分别静注盐酸利多卡因,一次剂量分别为25、75及100mg。按规定时间静脉采血样,分离血清,测定游离的药物浓度。结果如下:分布容积各为3.2、3.9及3.3升/公斤;消除半衰期各为1.8、2.0及2.1小时;总清 Previous studies of lidocaine pharmacokinetics in vivo showed that lidocaine plasma-concentration profiles were shown to accumulate when continuous infusion was significantly above the usual dose, thereby envisaging lidocaine in the human body Pharmacokinetics may depend on dose. The authors analyzed the pharmacokinetic profile of lidocaine at more than four times the usual dose for healthy volunteers. The authors randomized seven healthy adult male volunteers into three groups randomly: intravenous injection of lidocaine hydrochloride at a single dose of 25, 75, and 100 mg respectively. Blood samples were collected by venous blood according to the stipulated time, serum was separated and free drug concentration was measured. The results are as follows: distribution volume of 3.2, 3.9 and 3.3 liters / kg each; elimination half-life of 1.8, 2.0 and 2.1 hours each; total clear