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由于现代化疗的迅速发展,对治疗临床上许多细菌感染发挥重要作用,使疾病得到扩制。但仅靠化疗是不够的,尤其是免疫力低下的患者,常常在严重感染时仅使用化疗无明显效果,需要机体抵抗力或免疫力配合提高化疗效果。本文介绍新的半合成头孢菌素——AC-1370(其结构如图示),研究其对吞噬细胞的吞噬功能及其作用机制。吞噬细胞从小鼠腹腔液和小鼠周围以及人周围血液分离的中性白细胞,与药物混合进行组织培
Due to the rapid development of modern chemotherapy, it plays an important role in the treatment of many bacterial infections in clinical practice, and makes the disease expand. But chemotherapy alone is not enough, especially in patients with low immunity, often only used in severe infections with no significant effect of chemotherapy, the need for body resistance or immunity to improve the efficacy of chemotherapy. This article describes a new semi-synthetic cephalosporin - AC-1370 (the structure shown) to study its phagocytic phagocytic function and its mechanism of action. Phagocytic cells were isolated from the peritoneal fluid of mice and neutrophils isolated from the perihematomal and perihematomal tissues of mice and mixed with drugs for tissue culture