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Infect Dis J.-1994,13(1).-22～26作者对2组婴儿接种百日咳类毒素,每剂25μg.第1组69人,在3、5、7月龄注射;第2组76人,在3、5、12月龄注射.所有菌苗均接种于大腿前外侧深部皮下.每次注射后3和7天,电话询问儿童的父母有关局部和全身反应情况.于第1次、第3次注射前和第3次注射后1个月收集血样.当儿童2和3岁时,再取第4和第5份血样.用ELISA检测IgG、IgM和IgA抗百日咳毒素抗体,用中国仓鼠卵巢细胞测定法检
Infect Dis J.-1994,13 (1) .- 22 ~ 26 The authors inoculated two groups of infants with pertussis toxoid at a dose of 25 μg per group, with 69 in group 1 injected at 3, 5, and 7 months of age; group 2 76 People, at 3, 5, 12 months of age All vaccines were inoculated into the deep anterolateral thigh subcutaneously 3 and 7 days after each injection, the child was asked by telephone about local and systemic reactions.At the 1st, Blood samples were collected before the third injection and one month after the third injection, and the fourth and fifth blood samples were taken when the children were 2 and 3 years old. IgG, IgM and IgA anti-pertussis toxin antibodies were detected by ELISA, Hamster Ovary cell assay