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本工作通过动物实验对Ｋａｐｐａ受体激动剂以及经穴位高频电刺激治疗脊髓性肌痉挛的疗效及其机理进行研究。给家兔颈髓上施加逐渐增强的机械压迫，造成脊髓性肌痉挛的动物模型。鞘内注入Ｋａｐｐａ型阿片受体激动剂６６Ａ－０７８可产生明显的解痉效果，无论采用临床评价（Ａｓｈｗｏｒｔｈ评分）方法或电生理评价（Ｈ反射，肌紧张电位，腱反射）方法，均证明Ｋａｐｐａ受体激动剂可改善痉挛。该效应可被阿片受体拮剂纳洛酮所阻断。
This work through animal experiments on Kappa receptor agonists and acupoints by high-frequency electrical stimulation of spinal muscular spasm efficacy and mechanism were studied. Rabbit cervical spinal cord to impose a gradual increase in mechanical compression, resulting in spinal muscular spasm in animal models. Intrathecal injection of Kappa-type opioid receptor agonist 66A-078 produced a significant antispasmodic effect, both with clinical evaluation (Ashworth score) method or electrophysiological evaluation (H reflex, muscle tension, tendon reflex) method, both proved Kappa Receptor agonists improve spasticity. This effect can be blocked by the opioid receptor antagonist naloxone.