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目的探讨高危型人乳头状瘤病毒(HR-HPV)检测在宫颈病变筛查中的价值。方法分析380例同时行HR-HPV检测、液基细胞学检查和活组织病理学检查的宫颈病变筛查患者的临床资料。结果以活检宫颈上皮内瘤样变Ⅰ级(CINI)及CINI以上判定为活检阳性,活检阳性组HR-HPV感染率(85.4%)与阴性组(39.1%)相比,差异有高度统计学意义(P<0.01),CINⅠ、CINⅡ、CINⅢ和宫颈癌组HR-HPV感染率分别为77.5%、85.3%、91.9%和100%。细胞学检查为宫颈上皮内病变阴性(NILM)病例中,HR-HPV阳性组活检阳性率(47.4%)与阴性组(28.1%)相比;意义不明确的不典型鳞状细胞(ASCUS)病例中,HR-HPV阳性组活检(阳性率65.1%)与阴性组(23.4%相比;低度和高度鳞状上皮内病变(LSIL,HSIL)病例中,HR-HPV阳性组活检阳性率(88.6%)与阴性组(15.8%)相比;以上各组差异均有统计学意义(P<0.05或P<0.01)。结论 HR-HPV感染率与宫颈病变严重程度呈正相关,HR-HPV检测在宫颈病变筛查中有很重要的临床价值。
Objective To investigate the value of high-risk human papilloma virus (HR-HPV) in screening cervical lesions. Methods The clinical data of 380 patients with cervical lesions who underwent simultaneous HR-HPV testing, liquid-based cytology and biopsy were analyzed. Results The results of biopsy-positive cervical intraepithelial neoplasia grade Ⅰ (CINI) and CINI were positive for biopsy. The positive rate of HR-HPV infection in biopsy-positive group (85.4%) was significantly higher than that in negative group (39.1%) (P <0.01). The infection rates of HR-HPV in CINⅠ, CINⅡ, CINⅢ and cervical cancer group were 77.5%, 85.3%, 91.9% and 100% respectively. Cytology was negative for cervical intraepithelial neoplasia (NILM), HR-HPV-positive biopsy-positive (47.4%) compared with negative (28.1%); undetermined significance of atypical squamous cell (ASCUS) cases HR-HPV-positive group biopsy (positive rate was 65.1%) compared with the negative group (23.4%; low-grade and high-grade squamous intraepithelial lesion (LSIL) %) Was significantly higher than that in the negative group (15.8%). The differences among the above groups were statistically significant (P0.05 or P0.01) .Conclusion The HR-HPV infection rate is positively correlated with the severity of cervical lesions. HR- Cervical lesions screening has very important clinical value.