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通过生物信息学分析,研究者们发现基底样和三阴性乳腺癌中Rho GTP酶Rnd1是一个潜在的肿瘤转移抑制因子。敲除Rnd1蛋白破坏了上皮细胞的粘连和极性,导致上皮-间质细胞转化的发生,同时胞内的c-Myc表达发生紊乱、肿瘤抑制因子p53受到抑制,也导致了细胞产生肿瘤化转变。机制研究显示Rnd1通过激活Plexin B1蛋白的GAP结构域抑制Ras信号的传导,从而抑制Rap1的功能。而在乳腺上皮细胞中抑制Rap1会
By bioinformatics analysis, the researchers found that Rho GTPase Rnd1 is a potential tumor metastasis suppressor in both basal-like and triple-negative breast cancers. Knockout of the Rnd1 protein disrupts the adhesion and polarity of epithelial cells, resulting in epithelial-mesenchymal transition, as well as disruption of intracellular c-Myc expression and suppression of the tumor suppressor p53, resulting in tumorigenic transformation of cells . Mechanism studies show that Rnd1 inhibits the function of Rap1 by inhibiting the transduction of Ras signaling by activating the GAP domain of Plexin B1 protein. While inhibiting Rap1 in mammary epithelial cells