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目的:分析研究乳腺浸润性小叶癌的临床病理特征与诊断鉴别结果。方法:回顾性分析30例乳腺浸润性小叶癌患者的临床资料,运用免疫组化SP法以及光镜检查法对其进行整理与分析。结果:光镜下的细胞界限较为清晰、癌细胞体积较小、嗜酸性强、粘附性差、细胞核呈现出卵圆形,癌细胞的排列呈单行串珠状或围绕着遗留导管呈现出同心圆状的浸润。利用免疫组化SP法对这些患者进行检查发现,PR为60%～75%,ER为76%～97%,C-erb呈现出阴性特征。结论:在加强对乳腺浸润性小叶癌临床病理的研究与分析,有助于为乳腺浸润性小叶癌疾病的治疗提供专业的数据资料与图像资料,以提升该病的临床治疗水平与患者的生存质量,另乳腺浸润性小叶癌在乳腺浸润性癌群体中的比例为6%～15%,且发病年龄不断提前。
Objective: To analyze the clinicopathological features and differential diagnosis of breast invasive lobular carcinoma. Methods: The clinical data of 30 patients with invasive lobular carcinoma of the breast were retrospectively analyzed. The immunohistochemical SP method and light microscopy were used to sort out and analyze the data. Results: The cell boundaries were clear under light microscope. The cancer cells were small in size, strong in eosinophilicity and poor in adhesion. The nuclei showed oval, the arrangement of cancer cells was single beaded or concentric around the left ventricle Infiltration. Examination of these patients using immunohistochemical SP method found that PR was 60% -75%, ER was 76% -97%, C-erb showed negative features. Conclusion: To strengthen the clinicopathological study of breast invasive lobular carcinoma, and to help breast invasive lobular carcinoma disease treatment provides professional data and image data to enhance the clinical treatment of the disease and the patient’s survival Quality, and the other breast invasive lobular carcinoma in breast invasive cancer population in the ratio of 6% to 15%, and the age of onset continue to advance.