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目的研究山芝麻水提取物对鸭乙肝病毒(DHBV)的抗病毒与保护肝细胞的作用。方法将DHBV-DNA阳性的麻鸭随机分为高、中、低剂量山芝麻组、拉米夫定组和模型组,分别给予相应药物进行干预,并于用药前、用药第7、14天及停药后第7天取静脉血,检测血清中DHBV-DNA滴度和DHBsAg水平,以及测定丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和总胆红素(TBiL)的含量。实验结束时,取肝脏组织作病理学检查。结果与模型组比较,山芝麻高剂量组、拉米夫定组用药后血清中DHBV-DNA、DHBsAg、ALT/AST的水平均明显降低(P<0.05或P<0.01),停药后7 d,山芝麻高剂量组的DHBV-DNA、DHBsAg、ALT/AST仍能维持在较低水平(P<0.05),而拉米夫定组则出现明显反跳现象;山芝麻中剂量组显示有一定的效果,小剂量组无明显抑制作用。山芝麻各剂量组血清中TBiL水平没有明显变化(P>0.05)。镜下观察山芝麻高剂量组与阳性药组鸭肝脏的病理改变有一定的改善。结论山芝麻连续用药后有一定的抗炎及护肝作用。
Objective To study the anti-virus effect and protective effect of Sesame extract on Duck Hepatitis B virus (DHBV). Methods DHBV-DNA positive ducks were randomly divided into high, medium and low dose mountain sesame group, lamivudine group and model group, respectively, given the corresponding drugs for intervention, and before treatment, on the 7th and 14th day after treatment Venous blood was taken on the seventh day after drug withdrawal, serum DHBV-DNA titer and DHBsAg level were measured, and alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin TBiL) content. At the end of the experiment, the liver tissues were taken for pathological examination. Results Compared with the model group, the serum levels of DHBV-DNA, DHBsAg and ALT / AST in the high-dose sesame and lamivudine groups were significantly decreased (P <0.05 or P <0.01) , DHBV-DNA, DHBsAg and ALT / AST in the high-dose sesame mountain group were still low (P <0.05), while lamivudine group showed a significant rebound phenomenon; the middle sesame dose group showed a certain The effect of low-dose group had no significant inhibitory effect. The serum levels of TBiL in each dose of sesame seeds did not change significantly (P> 0.05). Microscopic observation of high-dose sesame mountain group and positive group of duck liver pathological changes have been some improvement. Conclusion Sesame sedum has certain anti-inflammatory and hepatoprotective effects after continuous administration.