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The enantioselective esterification of racemic 1-trimethylsilylethanol with acids catalyzed by lipase in organic solvent was successfully performed.The influence of some factors on the reaction was investigated.Among the four lipases explored,Candida rugosa lipase(CRL)showed the highest activity and enantioselectivity.Octanoic acid was the best acyl donor among the eleven acids studied and n-hexane was the most suitable medium for the reaction.The optimum shaking rate and temperature were found to be 150 r·min-1 and 20°C to 30°C,respectively.The enantiomeric excess of the remaining(S)-(-)-1-trimethylsilylethanol was 93% when substrate conversion was 53% upon incubation of the reaction mixture at 30°C,150 r·min-1 for 12 h.