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2型糖尿病患者发生大血管并发症的主要病理基础为动脉粥样硬化,且发生早、进展快、预后差、死亡率高,其引发的心脑血管疾病是糖尿病患者致死致残的主要原因之一。血尿酸是动脉粥样硬化的危险因素,与代谢综合征的多种成分,如肥胖、血脂异常、糖尿病、高血压、冠心病、胰岛素抵抗等密切相关。本文阐述2型糖尿病患者动脉粥样硬化发生中血尿酸的作用机制。
The main pathological basis of macrovascular complications in patients with type 2 diabetes is atherosclerosis, with early onset and rapid progression, poor prognosis and high mortality. Cardiovascular and cerebrovascular diseases are the main causes of death and disability in diabetic patients one. Serum uric acid is a risk factor for atherosclerosis and is closely related to various components of the metabolic syndrome such as obesity, dyslipidemia, diabetes, hypertension, coronary heart disease and insulin resistance. This article describes the role of serum uric acid in the development of atherosclerosis in type 2 diabetic patients.