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目的研究胸苷酸合成酶(thymidylate synthase,TS)基因5’-非翻译区(untranslated re- gion,UTR)、3’-UTR多态性及其与饮酒之间的联合作用和结直肠癌(colorectal cancer,CRC)易感性的关系。方法采用病例对照研究(140例病例和343例对照)设计,通过非条件Logistic回归模型和似然比检验分析TS上述多态性及其与饮酒之间的联合作用和CRC易感性之间的关系。结果单独的TS 基因多态性与CRC之间无明显联系。两多态性之间联合作用的P值为0．05。无饮酒史者中,+6 bp 等位基因是CRC的保护因素(OR=0．57,95％CI,0．32-0．99),有饮酒史者中,+6 bp等位基因携带者患CRC的风险增加(OR=1．88,95％CI,0．80-4．41),并且随着饮酒年限的延长,OR值逐渐升高。似然比检验提示两者之间存在交互作用(P=0．01)。结论尚不能认为TS基5’-UTR和3’-UTR多态性是CRC风险的独立预测因子,两多态性之间、3’-UTR多态性与饮酒之间存在交互作用,共同改变个体罹患结直肠癌的风险。
Objective To study the 5’-untranslated re-gion (UTR) and 3’-UTR polymorphisms of thymidylate synthase (TS) gene and their association with alcohol consumption and colorectal cancer ( Colorectal cancer, CRC) susceptibility relationship. Methods A case-control study (140 cases and 343 controls) was designed to analyze the relationship between TS polymorphisms and their association with alcohol consumption and susceptibility to CRC through unconditional logistic regression models and likelihood ratio tests. . Results There was no significant association between TS gene polymorphism and CRC alone. The combined P value of the two polymorphisms was 0.05. Among those who did not drink alcohol, the +6 bp allele was a protective factor for CRC (OR=0.57, 95% CI, 0.32-0.99). Among those who had a history of drinking, the +6 bp allele was carried. The risk of developing CRC increased (OR=1.88, 95%CI, 0.80-4.41), and the OR increased gradually with the extension of drinking years. The likelihood ratio test suggested that there was an interaction between the two (P=0.01). Conclusions The TS-based 5’-UTR and 3’-UTR polymorphisms cannot be considered as independent predictors of CRC risk. There are interactions between the two polymorphisms, 3’-UTR polymorphisms and alcohol consumption, and they may change together. Individuals are at risk for colorectal cancer.