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目的对我院2009年至2014年6月,5750例孕中期各种高危因素做羊水染色体核型检出的结果进行分析。方法在无菌条件下,由B超定位抽取羊水细胞培养,常规收获,G显带,核型分析后进行统计分析。结果共检出异常核型208例,异常检出率为3.62%(208/5750),其中染色体数目异常124例,占染色体异常核型百分比为59.61%,结构异常84例,占染色体异常核型百分比40.4%。非整体核型仍然以21三体综合征发病率最高,占所有染色体异常的28.36%,结论染色体核型检出对具有不同产前诊断指征的孕妇行羊膜腔穿刺术,指导临床干预具有重要的价值。
Objective To analyze the results of karyotype detection of various amniotic fluid chromosomes in our hospital from 2009 to June 2014 and 5750 middle-stage pregnancies. Methods Under aseptic conditions, amniotic fluid cultures were harvested by B-ultrasonography, and routinely harvested, G-banding and karyotype analysis were performed for statistical analysis. Results A total of 208 abnormal karyotypes were detected, the rate of abnormality was 3.62% (208/5750). There were 124 cases with abnormal chromosome number, 59.61% with karyotype abnormality, 84 with abnormal structure, accounting for chromosomal abnormal karyotype Percentage 40.4%. Non-integral karyotype still trisomy 21 the highest incidence, accounting for 28.36% of all chromosomal abnormalities, Conclusion chromosome karyotype detection of pregnant women with different prenatal diagnosis of amniocentesis, guidance of clinical intervention is important the value of.