1929年Witebsky提出肿瘤特异性抗原的概念,大大地推动了肿瘤研究。但迄今所获肿瘤抗原都是相对特异的。最近用单克隆抗体鉴定和提纯的肿瘤抗原越来越多,惜其临床应用尚少,近年肿瘤免疫研究对临床有重要意义的除AFP对原发性肝癌的诊断外,当推放射性核素标记抗体对肿瘤的放射免疫定位及单 In 1929, Witebsky proposed the concept of tumor-specific antigen, which greatly promoted tumor research. However, the tumor antigens obtained so far are relatively specific. Recently, more and more tumor antigens have been identified and purified using monoclonal antibodies. Unfortunately, clinical applications are rare. In recent years, tumor immune studies have been clinically important in addition to AFP diagnosis of primary liver cancer. Radioimmunolocalization of antibodies against tumors and single