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为了进一步探讨在高原条件下慢性心肌缺氧性损伤的病理形态学变化和中药丹参对该损伤的保护作用,本实验用大鼠28只,随机分为实验组(注射丹参组)和对照组(注射生理盐水组)将大鼠于6日内从海平面携入高原(海拔3416m)在该地生存8周后处死,对大鼠心肌的光镜和超微结构的变化进行了观察。结果发现,大鼠心肌呈现较弥漫的损伤,包括心肌细胞本身的病变和心肌微循环障碍两方面。同时观察到丹参对该条件下的心肌损伤具有显著的保护作用。作者推测,丹参的这种作用是通过多种途径实现的,
In order to further explore the pathological changes of chronic myocardial hypoxic injury under high altitude conditions and the protective effect of Salvia miltiorrhiza on this injury, 28 rats were randomly divided into experimental group (Salvia miltiorrhiza injection group) and control group Injected saline group). The rats were brought into the plateau (3416m above sea level) from the sea level within 6 days after being survived for 8 weeks. The light microscopy and ultrastructural changes in the myocardium of the rats were observed. The results showed that the rat myocardium showed more diffuse injury, including myocardial cell damage and myocardial microcirculation in two ways. Salvia miltiorrhiza also showed a significant protective effect on myocardial injury under this condition. The authors speculate that Salvia this role is achieved through a variety of ways,