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1982年从两个肢端肥大症的胰腺瘤中分离出三个具有促进生长激素释放活性的肽(hpGRF);1984年又从人的下丘脑分离出两个长链的肽(hGRF44-NH_?和hGRF 40-OH).合成的GRF也能促进动物和人的生长激素释放,副作用小.本文观察了hGRF的药代动力学过程.受试者分三组静脉注射不同剂量(2.5～80,80～320和75～600μg)的GRF,不同时间取血,用放射免疫技术测定血清中有免疫反应的GRF含量.
Three hGPGRF peptides were isolated from pancreatic tumors of two acromegaly in 1982 and two long-chain peptides (hGRF44-NH?) Were isolated from human hypothalamus in 1984. And hGRF 40-OH.) The synthetic GRF can also promote the release of growth hormone in animals and humans with little side effects.In this paper, we observed the pharmacokinetics of hGRF.The subjects were divided into three groups by intravenous injection of different doses (2.5-80, 80 ~ 320 and 75 ~ 600μg), and the blood samples were collected at different time. The level of GRF in the serum was detected by radioimmunoassay.