论文部分内容阅读
目的 观察大黄对全身炎症反应综合征 (简称SIRS)患儿炎性因子、补体的影响 ,以探讨大黄对SIRS的作用机制。方法 40例SIRS患儿在综合治疗的基础上给予生大黄粉口服或鼻饲 ,患儿入院时及入院后 48h对观察组测定血清TNF α、IL 1、IL 6、C RP、C3 及C4,并与 38例SIRS患儿常规治疗组及 30例正常对照组进行比较。并观察大黄对SIRS患儿的预后影响。结果 SIRS患儿入院时血清TNF α、IL 1、IL 6、C RP、C3 及C4显著高于正常对照组 ,随着病情缓解 ,上述指标有不同程度下降 ,且经大黄治疗后下降更明显。 结论 大黄能改善SIRS患儿的预后 ,其主要机制是大黄对炎性因子、补体有拮抗作用
Objective To observe the effect of rhubarb on the inflammatory cytokines and complement in patients with systemic inflammatory response syndrome (SIRS), and to explore the mechanism of action of rhubarb on SIRS. Methods 40 cases of SIRS children were treated with rhubarb powder or nasal feeding on the basis of comprehensive treatment. The serum levels of TNFα, IL 1, IL 6, C RP, C3 and C4 in the observation group were measured at admission and 48h after admission And 38 patients with SIRS routine treatment group and 30 normal control group were compared. And observe rhubarb on the prognosis of children with SIRS. Results Serum levels of TNFα, IL 1, IL 6, C RP, C3 and C4 in children with SIRS were significantly higher than those in the normal control group. The above indexes decreased to some extent with the remission, and the changes were more obvious after rhubarb treatment. Conclusion Rhubarb can improve the prognosis of children with SIRS. The main mechanism is that rhubarb has antagonistic effect on inflammatory factors and complement