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【目的】探讨匹多莫德联合雷诺考特治疗儿童鼻后滴漏综合征（PNDS）的疗效。【方法】102例PNDS患儿随机分为对照组（C组）、雷诺考特组（R组）和雷诺考特联合匹多莫德组（R＋ P组），每组34例。C组主要根据患儿的病因进行相关的治疗，R组在C组治疗的基础上给予雷诺考特喷鼻，R＋ P组在R组治疗的基础上给予匹多莫德口服。治疗结束后比较三组患儿的治疗效果和治疗满意度；治疗结束后随访3个月，观察三组患儿的复发情况。【结果】三组患儿的治疗效果差异具有统计学意义（ P ＜0．05），三组患儿的复发率和治疗满意度差异无统计学意义（P ＞0．05）。R组与C组之间的治疗效果、复发率和治疗满意度差异无统计学意义（P ＞0．05）；R＋ P组与R组之间的治疗效果、复发率和治疗满意度差异无统计学意义（ P ＞0．05）；R＋ P组的治疗效果、复发率和治疗满意度显著优于C组，差异具有统计学意义（ P ＜0．05）。【结论】匹多莫德联合雷诺考特治疗儿童PNDS能够提升治疗效果，降低复发率。“,”[Objective] To explore the efficacy of combining Ray Naukauot and pidotimod for postnasal drip syndrome (PNDS) in children .[Methods]A total of 102 patients with PNDS were randomly divided into control , Ray Naukauot (R) and pidotimod (P) groups ( n =34 each) .The control group received related treatments ,the Ray Naukauot group had additional Ray Naukauot nasal spray and the pidotimod group took oral pidotimodthe . The efficacies and treatment satisfaction were compared among 3 groups after the end of treatment .Over a follow‐up period of 3 months ,the recurrence rates of 3 groups were observed .[Results] The differences among 3 groups had statistical significance in efficacy ( P 0 .05) .Between Ray Naukauot and control groups in efficacy ,recurrence rate and treatment satis‐faction showed no significant difference ( P >0 .05) .No significant difference existed in efficacy ,recurrence rate or treatment satisfaction between pidotimod and Ray Naukauot groups ( P >0 .05) .Efficacy ,recurrence rate and treatment satisfaction were significantly better in pidotimod group than those in control group .And the differences were statistically significant ( P <0 .05) .[Conclusion] A combination of pidotimod and Ray Naukauot may boost the efficacy and reduce recurrence rate in the treatment of postnasal drip syndrome in children .