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目的 :比较分析不同月龄段大鼠胃固体、液体排空率及血清 -胃肠粘膜中GAS、MTL、SS水平变化。方法 :用同位素99mTc灌胃法测定大鼠胃固体、液体排空率 ,用放射免疫法 (RIA )测定血清、胃肠粘膜中GAS、MTL、SS水平并进行比较分析。结果 :液体排空率随老化明显下降 ;血清中胃肠激素水平老化改变不明显 ,但胃粘膜中GAS与SS水平明显升高。结论 :随老化胃液体排空延缓可能与胃粘膜中SS升高有关 ,而GAS升高有助于维持基本正常的胃内酸环境。
OBJECTIVE: To comparatively analyze the gastric solid and fluid emptying rate and the changes of GAS, MTL and SS in serum and gastrointestinal mucosa of rats of different ages. Methods: Gastric emptying rate and gastric emptying rate in rats were determined by isotonic 99mTc gavage. The levels of GAS, MTL and SS in serum and gastrointestinal mucosa were determined by radioimmunoassay (RIA) and compared. Results: The rate of fluid evacuation obviously decreased with the aging. The serum level of gastrointestinal hormone did not change obviously. However, the levels of GAS and SS in gastric mucosa were significantly increased. CONCLUSIONS: Delayed emptying of gastric fluid with aging may be associated with an increase in SS in gastric mucosa, whereas elevated GAS may help maintain a substantially normal intragastric acid environment.