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目的探讨川芎嗪注射液辅助治疗妊娠高血压综合征的有效性和安全性。方法选取2012年3月—2014年1月我院收治的妊娠高血压综合征患者48例,将其随机分为对照组和观察组,各24例。两组患者均给予低流量吸氧、镇静、解痉和降压等治疗,在此基础上对照组患者给予硫酸镁治疗,观察组患者给予硫酸镁联合川芎嗪注射液治疗,均连续治疗14 d。比较两组患者临床疗效、治疗前后肾功能指标及治疗期间不良反应情况。结果观察组患者总有效率为91.7%,高于对照组的66.7%(P<0.05)。治疗前两组患者血尿素氮、肌酐和尿酸水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血尿素氮、肌酐和尿酸水平均低于对照组(P<0.05)。两组患者治疗期间均未出现严重不良反应。结论川芎嗪注射液辅助治疗妊娠高血压综合征疗效确切,可有效改善患者临床症状及肾功能,且安全性较高。
Objective To investigate the efficacy and safety of ligustrazine injection in the treatment of pregnancy-induced hypertension syndrome. Methods Forty-eight patients with pregnancy-induced hypertension who were treated in our hospital from March 2012 to January 2014 were randomly divided into control group and observation group, with 24 cases in each group. Two groups of patients were given low-flow oxygen, sedation, spasm and blood pressure treatment, on the basis of the control group of patients given magnesium sulfate treatment, the observation group was given magnesium sulfate combined with ligustrazine injection, were treated for 14 days . The clinical curative effect, the renal function index before and after treatment and the adverse reaction during the treatment were compared between the two groups. Results The total effective rate in observation group was 91.7%, which was higher than that in control group (66.7%, P <0.05). There was no significant difference in blood urea nitrogen, creatinine and uric acid levels between the two groups before treatment (P> 0.05). After treatment, the levels of blood urea nitrogen, creatinine and uric acid in the observation group were lower than those in the control group (P <0.05). Two groups of patients during the treatment did not appear serious adverse reactions. Conclusion Ligustrazine injection adjuvant treatment of pregnancy-induced hypertension syndrome curative effect is exact, can effectively improve the clinical symptoms and renal function, and high safety.