自1976年哌唑嗪(prazosine)用于临床以来,已在高血压、心衰、嗜铬细胞瘤等的治疗方面取得显著疗效。但长期应用后突然停药,可发生停药综合征,使病情恶化甚至死亡。现报告三例如下。例1 男,72岁,因反复心悸咳喘、浮肿3年,加重4～5天,于1985年11月23日入院。患者于1981年9月曾患“急性广泛前壁心肌梗塞”。几年来因心衰 Since prazosine was used clinically in 1976, it has been shown to be effective in the treatment of hypertension, heart failure, pheochromocytoma and the like. However, after a long-term application of sudden withdrawal, withdrawal syndrome may occur, so that the disease worsened or even died. The following three reports are as follows. Example 1 Male, 72 years old, due to repeated palpitations cough, edema 3 years, increased 4 to 5 days, on November 23, 1985 admission. The patient had “acute extensive anterior myocardial infarction” in September 1981. In recent years due to heart failure