在已报道的四十多种手性衍生化试剂中,异氰酸酯是应用研究最活跃的一类。目前,这类试剂只有(R)-(-)或(S)-(+)-naphthylethyl isocyanate(NEIC)和(R)-(+)或(S)-(-)-phenylethyl isocyanate(PEIC)两种。它们均由相应的手性伯胺化合物,经光气或氯甲基硅烷作用得到的。但光气是毒性极大的气体,在一般实验室条件下难以得到 Of the more than forty chiral derivatizing agents reported, isocyanates are the most active class of applied research. At present, only (R) - (-) or (S) - (+) - naphthylethyl isocyanate (NEIC) and (R) - (+) or (S) --phenylethyl isocyanate (PEIC) Species. Both of them are obtained from the corresponding chiral primary amine compounds via phosgene or chloromethylsilane. Phosgene, however, is a highly toxic gas that is difficult to obtain under normal laboratory conditions