为减少喜树碱结构在碱性条件下的内酯环开环反应,将微波技术应用于10-羟基喜树碱的醚化反应中,与常规加热条件相比,微波反应不仅极大地缩短了反应时间,同时也将反应收率从20%～30%显著地提高到50%～83%.这一研究结果对喜树碱的其他类型反应也具有可借鉴作用. In order to reduce the ring-opening reaction of lactone ring with camptothecin structure under alkaline conditions, the microwave technique was applied to the etherification of 10-hydroxycamptothecin. Compared with the conventional heating conditions, the microwave reaction was not only greatly reduced Reaction time, but also the reaction yield was significantly increased from 20% to 30% to 50% to 83% .This study also has reference to other types of camptothecin reaction.