炎症的消散是一个需要十分精确调节的动态过程 ,受体内外多种因素的影响 ,包括内源性“刹车信号”的产生 ,聚集的白细胞的清除等。炎症时机体内有整套的内源性保护机制存在 ,尤其是内源性抗炎介质的产生。近年来的研究表明 ,机体内的内源性保护介质主要有cAMP、脂毒素、环戊烯前列腺素(cyPGs)和磷脂氧化产物。本文综述了内源性抗炎介质在炎症消散过程中的作用。模拟体内抗炎介质的产生 ,可以人工合成治疗炎症的新药物 The dissipation of inflammation is a dynamic process that requires very precise regulation, influenced by a number of factors both inside and outside the body, including the generation of endogenous “brake signals” and the depletion of aggregated leukocytes. There is a whole body of endogenous protective mechanisms in the body at the time of inflammation, especially the production of endogenous anti-inflammatory mediators. In recent years, studies have shown that the body’s endogenous protective media are cAMP, lipotoxins, cyclopentene prostaglandins (cyPGs) and phospholipid oxidation products. This article reviews the role of endogenous anti-inflammatory mediators in the dissipation of inflammation. Simulate the production of anti-inflammatory mediators in the body, artificial synthesis of new drugs for the treatment of inflammation