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近年来研究证实,人体细胞如淋巴样细胞,红细胞、嗜中性粒细胞,单核细胞、肝细胞及肾小球上皮细胞表面均具有C_3b与C_3d或C_3b/C_3d受体,关于各种细胞C_3受体的作用,除C_3受体介导嗜中性粒细胞和单核细胞的吞噬作用外,其它作用了解得很少。为了证实C_3受体的作用,作者用EAC(抗羊红细胞抗体致敏的绵羊红细胞与兔的补体结合的复合物)与人体扁桃腺细胞C_3受体活性溶解产物(C_3蛋白)制成EAC—C_3受体复合物,免疫家兔获得抗人C_3受体抗血清,并用此血清对人体各种细胞C_3受体的特异性抑制作用进行了研究。
In recent years, studies have confirmed that human cells such as lymphoid cells, erythrocytes, neutrophils, monocytes, hepatocytes and glomerular epithelial cells have C_3b and C_3d or C_3b / C_3d receptors on various cell C_3 The role of the receptor, in addition to C_3 receptor mediated phagocytosis of neutrophils and monocytes, the role of other little understood. To confirm the role of C_3 receptor, the authors made EAC-C_3 by EAC (complex of sheep erythrocytes and rabbit complement sensitized with anti-sheep erythrocyte antibody) and human C 3 receptor activity lysate (C_3 protein) of human tonsil The anti-human C 3 receptor antiserum was obtained from the immunized rabbits and the specific inhibitory effect of this serum on the C 3 receptor of various human cells was studied.