论文部分内容阅读
目的探讨丙型病毒性肝炎(丙肝)患者配偶感染HCV风险及其影响因素。方法选取重庆市南川区各医疗机构诊断的性活跃慢性丙肝患者96例及其配偶为研究组,性别、年龄匹配的因其他疾病入院患者(HCV筛查阴性)96例及其配偶为对照组,采集患者血清、配偶体液样本,检测患者体液带毒情况及配偶血清感染情况,并进行问卷调查。结果研究组96例患者体液抗-HCV/HCV RNA阳性人数23(23.96%)/40(41.67%),高于对照组(P<0.05),不同性别阳性率差异无统计学意义(P>0.05);研究组96例患者配偶或性伴血清抗-HCV/HCV RNA阳性人数22(22.92%)/27(28.12%),高于对照组(P<0.05),不同性别阳性率差异无统计学意义(P<0.05)。logistic回归分析模型结果显示,低安全套使用频率(OR=0.483,95%CI=0.280~0.736)、结婚年限长(OR=1.838,95%CI=1.177~3.980)是配偶阳性的独立危险因素。结论慢性丙肝患者配偶感染风险较高,患者体液带毒率较高,安全套使用、结婚年限是感染的影响因素,配偶感染可能与性传播有关。
Objective To investigate the risk of spouse infection with HCV in hepatitis C virus (HCV) and its influencing factors. Methods Ninety-six patients and their spouses of sexually active chronic hepatitis C diagnosed by various medical institutions in Nanchuan District of Chongqing were selected as the study group, 96 gender-matched age-matched patients with other diseases (negative for HCV screening) and their spouses as the control group, Patient serum and spouse fluid samples were collected, the patient’s body fluid was taken out and the spouse’s serum was infected, and the questionnaire was conducted. Results The positive rate of anti-HCV / HCV RNA in the study group was 23 (23.96%) / 40 (41.67%) higher than that in the control group (P <0.05), and there was no significant difference between the sexes ). The positive number of anti-HCV / HCV RNA in the spouses or sexual partners of the study group was 22 (22.92%) / 27 (28.12%), higher than that of the control group (P0.05) Significance (P <0.05). Logistic regression analysis showed that the frequency of low condom use (OR = 0.483, 95% CI = 0.280-0.736) and longer marriage (OR = 1.838,95% CI = 1.177-3.980) were independent risk factors for the spouse’s positive. Conclusion There is a high risk of spouse infection in patients with chronic hepatitis C, the higher the rate of body fluid in patients with chronic convalescence, the use of condoms and the age of marriage are the influencing factors of infection. Spouse infection may be related to sexual transmission.