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目的分析超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(HCY)及胱抑素C(CysC)与冠心病的相关性。方法选取本院2015年5月至2017年3月收治的117例冠心病患者为研究对象,根据冠心病不同类型,将其分为3组,即39例稳定型心绞痛患者(SAP组),39例不稳定心绞痛患者(UAP组),39例急性心肌梗死(AMI组),并选择同期进行健康检查的39名健康者为(对照组)。对比4组人员的超敏C-反应蛋白、同型半胱氨酸及胱抑素C水平,并采用logistic回归分析hs-CRP、HCY及CysC与冠心病的相关性。结果稳定型心绞痛组、不稳定心绞痛组、急性心肌梗死组、对照组的hs-CRP、HCY及CysC水平差异具有统计学意义(P<0.05);排除其他影响因素,采用多元logistic回归分析对hs-CRP、HCY及CysC等指标进行统计学处理,发现影响冠心病发生的危险因素为hs-CRP、HCY及CysC(P<0.05)。结论 hs-CRP、HCY及CysC水平与冠心病相关,冠心病患者病情越严重,其hs-CRP、HCY及CysC水平越高。
Objective To analyze the correlation between high sensitivity C-reactive protein (hs-CRP), homocysteine (HCY) and cystatin C (CysC) and coronary heart disease. Methods A total of 117 patients with coronary heart disease admitted from May 2015 to March 2017 in our hospital were selected and divided into three groups according to different types of coronary heart disease: 39 patients with stable angina (SAP group), 39 (UAP group), 39 AMI patients (AMI group) and 39 healthy people who chose to undergo the same period of health check (control group). Hypersensitivity C-reactive protein, homocysteine and cystatin C were compared between the four groups. Logistic regression was used to analyze the correlation between hs-CRP, HCY, CysC and coronary heart disease. Results The levels of hs-CRP, HCY and CysC in stable angina group, unstable angina group, acute myocardial infarction group and control group were significantly different (P <0.05) .Multiple logistic regression analysis was used to analyze the hs -CRP, HCY and CysC and other indicators were statistically analyzed and found that the risk factors for the occurrence of coronary heart disease were hs-CRP, HCY and CysC (P <0.05). Conclusion The levels of hs-CRP, HCY and CysC are correlated with coronary heart disease. The more severe the patients with coronary heart disease, the higher the hs-CRP, HCY and CysC levels.