论文部分内容阅读
目的分析单纯性肾囊肿(SRC)对动脉血压的影响,揭示SRC与高血压之间的关系。方法选择2012年1月至2014年4月开滦集团接受健康体检的受检者91 433人为研究对象进行横断面研究。应用年龄、性别1∶3匹配的病例-对照配对分析和多因素Logistic回归模型分析SRC与动脉血压之间的关系。结果研究人群共检出SRC患者2465例(2.70%),男性SRC检出率高于女性(2.95%比1.68%,P<0.01)。随年龄增加,SRC检出率增加。配对分析结果显示,SRC组(n=2465)收缩压、高血压病史、高血压检出率、肾结石和尿蛋白阳性率高于无SRC组(n=7395)[分别为(137.4±20.3)比(135.9±19.3)mm Hg,17.00%比14.50%,58.82%比50.71%,7.06%比1.58%,7.46%比3.61%,均P<0.01],估算的肾小球滤过率低于无SRC组[(79.0±19.9)比(91.7±21.8)mL/(min·1.73m~2),P<0.01],但两组之间的舒张压差异无统计学意义[(85.6±11.0)比(83.5±10.6)mm Hg,P>0.05]。在SRC人群中,SRC直径≤2.0cm组和>2.0cm组的收缩压[(137.1±21.2)比(137.7±20.3)mm Hg,P=0.22]和舒张压[(85.2±12.4)比(85.9±11.7)mm Hg,P=0.49]以及高血压的检出率(57.33%比60.25%,P=0.14)的差异均无统计学意义。多因素分析显示SRC是高血压的危险因素[OR值(95%CI)为1.18(1.11~1.25)];SRC与收缩压升高密切相关(B=2.47,β=0.05,P<0.01)。SRC不伴肾结石组(n=2295)收缩压高于有肾结石无SRC组(n=1137)[(137.3±20.3)比(135.3±19.9)mm Hg,P=0.01]。结论 SRC多发于男性和老年人,是收缩期高血压的重要危险因素。
Objective To analyze the effect of simple renal cyst (SRC) on arterial blood pressure and to reveal the relationship between SRC and hypertension. Methods 91 433 subjects of Kailuan Group from January 2012 to April 2014 were selected as subjects for the cross-sectional study. The relationship between SRC and arterial blood pressure was analyzed by case-matched age-matched and sex-matched matched controls and multivariate Logistic regression model. RESULTS: A total of 2465 SRC patients (2.70%) were detected in the study population. The detection rate of SRC in male was higher than that in female (2.95% vs 1.68%, P <0.01). With age, SRC detection rate increased. The results of paired analysis showed that the systolic blood pressure, the history of hypertension, the detection rate of hypertension, the positive rate of kidney stones and urine protein in SRC group (n = 2465) were higher than those without SRC (n = 7395) (137.4 ± 20.3, (135.9 ± 19.3) mmHg, 17.00% vs 14.50%, 58.82% vs 50.71%, 7.06% vs 1.58%, 7.46% vs 3.61%, all P <0.01], and the estimated glomerular filtration rate was lower than SRC group (79.0 ± 19.9) vs (91.7 ± 21.8) mL / (min · 1.73m 2), P <0.01], but there was no significant difference in diastolic pressure between the two groups [(85.6 ± 11.0) vs (83.5 ± 10.6) mm Hg, P> 0.05]. In the SRC population, systolic blood pressure (137.1 ± 21.2) vs (137.7 ± 20.3) mm Hg, P = 0.22] and diastolic blood pressure (85.2 ± 12.4) vs (85.9 ± 11.7 mm Hg, P = 0.49] and the detection rate of hypertension (57.33% vs. 60.25%, P = 0.14). Multivariate analysis showed that SRC was a risk factor for hypertension (OR, 95% CI, 1.18 to 1.18). SRC was associated with an elevated systolic blood pressure (B = 2.47, β = 0.05, P <0.01). SRC without renal calculi (n = 2295) had a higher systolic blood pressure than those without SRC (n = 1137) [(137.3 ± 20.3) vs (135.3 ± 19.9) mm Hg, P = 0.01]. Conclusion SRC is more common in men and the elderly, and is an important risk factor for systolic hypertension.