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由于 3型副流感病毒 (PIV3)可在 6月龄以下婴儿中引起严重疾病 ,故应在存在母传抗体的婴儿早期进行免疫。本研究评价了MVA/PIV3重组体在输入含抗 - PIV3同种血清的恒河猴中的免疫原性和效果 ,并与 cp45PIV3减毒活疫苗进行比较。 MVA/PIV3重组体疫苗以在多数哺乳动物细胞内
Since parainfluenza type 3 (PIV3) causes serious illness in infants under 6 months of age, it should be immunized early in infants with maternal antibodies. This study evaluated the immunogenicity and efficacy of MVA / PIV3 recombinants in rhesus monkeys fed anti-PIV3 allo-sera and compared with cp45 PIV3 live attenuated vaccine. MVA / PIV3 recombinant vaccines in most mammalian cells