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与每日用药数次的治疗方案相比,每日口服1次治疗A组β-溶血性链球菌(GABHS)咽炎的方案更为方便,尤其对正在上学的儿童更是如此.每日用药1次也可能会提高患者的依从性.药物动力学数据和临床经验提示,阿莫西林每日口服 1次可能对GABHS咽炎有效.Fedez等对阿莫西林 750mg每日口服 1次和青霉素V250mg每日口服3次(疗程皆为 10d)治疗GABHS咽炎的方案进行了一项前瞻性的随机对照研究.以临床检查提示为 GABHS咽炎的 3～18岁患者为研究对象,对治疗前的3种体征(发热、扁桃体肿胀和颈淋巴结肿大及压痛)和1种自觉症状(咽痛)以及治疗开始后18～24h的情况作了评估.作2种不同的咽拭子检查,并用Streptex试验证实了所有检出的β-溶血性链球菌均属A组.
It is more convenient to administer Group A β-hemolytic streptococcal (GABHS) pharyngitis once daily oral treatment, especially for children who are attending school, as compared to a treatment regimen that is administered several times per day. Times may also increase patient compliance.Pharmacokinetic data and clinical experience suggest that once daily oral administration of amoxicillin may be effective for GABHS pharyngitis.Fedez and other amoxicillin 750mg daily oral and penicillin V250mg daily A prospective, randomized, controlled trial of a regimen of GABHS pharyngitis administered orally 3 times (all for 10 days) was conducted in patients 3 to 18 years old with GABHS pharyngitis as the target of study, Fever, tonsil swelling and enlargement and tenderness of the cervical lymph nodes) and 1 subjective symptom (sore throat) and 18 to 24 hours after the start of the treatment. Two different throat swabs were examined and all were confirmed by the Streptex test Detection of β-hemolytic streptococcus belong to the A group.