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胰岛素样生长因子中的肽类或生长介素,除了能刺激整个个体生长外,对某些细胞还具有胰岛素样活性与促有丝分裂的能力。目前发现这些多肽对性腺具有作用,胰岛素祥生长因子 I(IGF-1)与 FSH有协同作用能增加大鼠与猪的卵泡颗粒细胞的孕酮合成与芳香化活性。最近又发现大鼠睾丸内含有IGF-1,人精液内也含有 IGF-1,一般认为 IGF-1来自性腺。现已证明 IGF 是由 Sertoli 细胞所分泌。Sertoli 细胞上有 IGF 的受体,能对 IGF 的促有丝分裂作用发生反应。IGF 对睾丸甾体激素的形成具有作用,推测可能是 Sertoli 细胞分泌 IGF-1与 IGF-2到睾丸液中,就近影响间质细胞,引起睾酮的产生。为了证实这一点,作者从3～4月的大鼠
Peptides or growth factors in insulin-like growth factors, in addition to stimulating the growth of an entire individual, also have insulin-like activity and mitogenic potential in certain cells. These peptides have now been found to have a role in gonadal development. Synergistic effects of insulin-like growth factor I (IGF-I) and FSH can increase progesterone synthesis and aromatise activity in rat and pig follicular granulosa cells. Recently found that rats contain testicular IGF-1, human seminal fluid also contains IGF-1, IGF-1 is generally believed that from the gonads. It has been demonstrated that IGF is secreted by Sertoli cells. Sertoli cells have IGF receptors that respond to the mitogenic effects of IGF. IGF plays a role in the formation of testosterone steroid hormones, presumably Sertoli cells secrete IGF-1 and IGF-2 to the testicular fluid, the recent impact of interstitial cells, causing testosterone production. To confirm this, the authors from 3 to 4 rats