论文部分内容阅读
目的探讨急性脑梗死(ACI)患者血清超敏C反应蛋白(hs-CRP)含量的变化及其与疾病严重程度的关系。方法对112例ACI患者(包括轻型38例、中型39例、重型35例)和40例健康体检者的血清hs-CRP含量进行测定分析。结果①治疗前ACI患者hs-CRP含量为(13.28±2.39)mg/L,治疗两周后为(2.91±1.08)mg/L,正常对照组hs-CRP含量为(2.58±0.65)mg/L。经统计学处理,ACI患者治疗前hs-CRP含量明显高于正常对照组(P<0.01),治疗两周后与正常对照组无显著差异(P>0.05);②轻型脑梗死组hs-CRP含量为(6.97±3.98)mg/L,中型脑梗死组hs-CRP含量为(15.12±7.98)mg/L,重型脑梗死组hs-CRP含量为(21.31±11.27)mg/L。各组间血清hs-CRP含量两两比较差异均有显著性(P<0.01),hs-CRP含量与其临床神经功能缺损程度评分呈正相关(r=0.676,P<0.01)。结论hs-CRP含量与脑梗死病情的严重程度呈正相关,对于急性脑梗死的诊断、病情监测具有实用价值。
Objective To investigate the changes of serum hs-CRP in patients with acute cerebral infarction (ACI) and its relationship with the severity of the disease. Methods The serum levels of hs-CRP in 112 patients with ACI (including 38 with light, 39 with medium, 35 with severe) and 40 healthy controls were measured. Results ① The hs-CRP level in ACI patients before treatment was (13.28 ± 2.39) mg / L, (2.91 ± 1.08) mg / L after two weeks and hs-CRP in normal control group was (2.58 ± 0.65) mg / L . Statistically, the content of hs-CRP in ACI patients before treatment was significantly higher than that in normal control group (P <0.01), and there was no significant difference between two groups (P> 0.05) (6.97 ± 3.98) mg / L, hs-CRP in middle cerebral infarction group was (15.12 ± 7.98) mg / L, and hs-CRP level in severe cerebral infarction group was (21.31 ± 11.27) mg / L. The levels of hs-CRP in each group were significantly different between two groups (P <0.01). The content of hs-CRP was positively correlated with the score of clinical neurological deficit (r = 0.676, P <0.01). Conclusion There is a positive correlation between the content of hs-CRP and the severity of cerebral infarction. It has practical value for the diagnosis and condition monitoring of acute cerebral infarction.