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Objective:To evaluate the effect of Chinese herbs decoction Shu-Gan-Liang-Xue on endocrine therapyassociated hot flashes symptom in breast cancerpatients. Methods:Sixty-six patients with breast cancer receiving adjuvant endocrine therapy were categorized to two groups,the control group received endocrine therapy alone,the other group is administered with Chinese herbs decoction Shu-Gan-Liang-Xue besides the endocrine therapy:Shu-Gan-Liang-Xue decoction was administered above 6 months per year for more than 2 years.Frequency of hot flashes per day was recorded,and the effect of Shu-Gan-Liang-Xue decoction on hot flashes symptom being assessed with Kupperman Scoring Index.Results:Sixty cases were analyzed,32 cases in endocrine therapy combining Chinese herbs decoction group,28cases in mere endocrine therapy group.For hot flashes symptom,in Chinese herbs decoction administration group,7 cases(21.9%)reported symptom disappeared,22 cases(68.7%)reported symptom alleviated,3 cases(9.4%)reported symptom not changed;in endocrine therapy alone group,S cases(17.9%)reported symptom disappeared,13 cases(46.4%)reported symptom alleviated,10 cases(10/28,35.7%)reported symptom not changed.The difference between two groups was statistically significant(P=0.013).For sleeping disorder,in Chinese herbs decoction administration group,27 cases(84.4%)reported symptom improved,5 cases(15.6%)reported no change;in endocrine therapy alone group,16 cases(57.1%)symptom improved,12 cases(42.9%)reported no change in sleeping disorder(P=0.019),the difference was also of significance statistically.Conclusion:Long-term Chinese herbs decoction administration remarkably improved hot flashes symptom and sleeping disorder associated with endocrine therapy,meanwhile without definite toxicity and influence on the risk of recurrence of tumor.