论文部分内容阅读
目的探讨前列腺癌(PCa)和前列腺增生(BPH)患者血清高敏C反应蛋白(hs-CRP)与Gleason评分的关系。方法分析261例经直肠前列腺穿刺活检患者病理诊断为PCa和BPH患者血清hs-CRP的差异,比较PCa患者hs-CRP增高和正常者高危性(Gleason评分≥7分)PCa患病率,运用Logistic回归分析hs-CRP、前列腺特异性抗原(tPSA)、前列腺特异性抗原密度(PSAD)、前列腺总体积(TPV)和年龄等因素对高危性PCa患病率的影响。结果 PCa患者血清hs-CRP的中位数为3.57mg/L,明显高于BPH患者的1.20mg/L(P<0.05)。在高危性PCa中hs-CRP为5.05mg/L,明显高于低危性PCa中的0.75mg/L(P<0.05)。PCa患者hs-CRP>3mg/L组高危性PCa患病率为94.23%(49/52),明显高于hs-CRP≤3mg/L组高危性PCa患病率59.45%(22/37)(P<0.05)。hs-CRP影响高危性PCa患病率的优势比(OR)为1.618(P<0.05)。结论 hs-CRP升高明显增加前列腺穿刺活检患者高危性PCa检出率;hs-CRP是影响高危性PCa患病率的独立因素。
Objective To investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP) and Gleason score in patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Methods The serum hs-CRP levels in 261 patients with pathologically diagnosed PCa and BPH were analyzed. The prevalence of PCa in patients with PCa was compared with that in patients with elevated hs-CRP and high-risk (Gleason score ≥7) Regression analysis hs-CRP, prostate-specific antigen (tPSA), prostate-specific antigen density (PSAD), total prostate volume (TPV) and age and other factors on the prevalence of high-risk PCa. Results The median serum hs-CRP level in PCa patients was 3.57 mg / L, which was significantly higher than that of BPH patients (1.20 mg / L, P <0.05). The hs-CRP in high-risk PCa was 5.05 mg / L, which was significantly higher than 0.75 mg / L in low-risk PCa (P <0.05). The prevalence of high risk PCa in PCa patients with hs-CRP> 3mg / L was 94.23% (49/52), significantly higher than that in high-risk patients with hs-CRP≤3mg / L 59.45% (22/37) P <0.05). The odds ratio (hs-CRP) of high risk PCa prevalence was 1.618 (P <0.05). Conclusions Increased hs-CRP significantly increases the detection rate of high-risk PCa in patients undergoing prostate biopsy. Hs-CRP is an independent factor affecting the prevalence of high-risk PCa.