收集8例乳腺原发性非何杰金淋巴瘤进行回顾性研究。6例临床诊断乳腺癌并行根治术，其中4例术中冰冻切片，均误诊为髓样痛和低分化癌。7例作了免疫组化检查，LCA全部阳性，其中6例L26阳性，1例UCHL1阳性，余1例为髓外装细胞瘤．提示乳腺恶性淋巴瘤多数为B淋巴细胞性。研究结果显示：本病在临床和病理诊断中易误诊为乳腺癌，免疫组化有助于鉴别诊断。 Eight primary breast non-Hodgkin lymphomas were collected for retrospective study. Six cases of clinically diagnosed breast cancer were treated with concurrent radical mastectomy. Among them, four cases of intraoperative frozen section were misdiagnosed as medullary pain and poorly differentiated carcinoma. In 7 cases, immunohistochemical examination was performed. All LCA were positive, including 6 cases of L26 positive, 1 case of UCHL1 positive, and the remaining 1 cases were myeloid cells. Prompt breast lymphoma is mostly B lymphocyte. The results of the study showed that this disease is often misdiagnosed as breast cancer in clinical and pathological diagnosis. Immunohistochemistry is helpful for differential diagnosis.