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目的探讨疏血通注射液联合桂哌齐特治疗短暂性脑缺血发作的临床疗效。方法选取2014年1月—2016年1月延安市人民医院收治的短暂性脑缺血发作患者132例,随机分为对照组和治疗组,每组各66例。对照组静脉滴注马来酸桂哌齐特注射液,320 mg加入生理盐水500 m L,1次/d;治疗组在对照组的基础上静脉滴注疏血通注射液,6 m L加入生理盐水250 m L,1次/d。两组均连续治疗14 d。观察两组患者的临床疗效,同时比较两组治疗前后血浆黏滞度(CP)、血细胞比容(HCT)、纤维蛋白原(FIB)、血小板聚集率(PAR)和ABCD评分的变化情况。结果治疗后,对照组和治疗组的总有效率分别为83.33%、93.94%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组CP、HCT、FIB和PAR显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标降低程度比对照组更明显,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组ABCD评分显著低于对照组,且其改善值优于对照组,两组ABCD评分变化比较差异具有统计学意义(P<0.05)。结论疏血通注射液联合桂哌齐特治疗短暂性脑缺血发作具有较好的临床疗效,可有效改善患者血液流变学相关指标,降低早期发生脑梗死的风险,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Shuxuetong injection combined with cinepazide in the treatment of transient ischemic attack. Methods 132 patients with transient ischemic attack admitted to Yan’an People’s Hospital from January 2014 to January 2016 were randomly divided into control group and treatment group with 66 cases in each group. The control group was given cinepazide maleate injection, 320 mg saline 500 m L, once a day. On the basis of the control group, Shuxuetong injection was given to the treatment group and 6 m L Saline 250 m L, 1 time / d. Both groups were treated for 14 days. The clinical effects of the two groups were observed. The changes of plasma viscosity (CP), hematocrit (HCT), fibrinogen (FIB), platelet aggregation rate (PAR) and ABCD score were compared between the two groups before and after treatment. Results After treatment, the total effective rates of the control group and the treatment group were 83.33% and 93.94%, respectively. There was significant difference between the two groups (P <0.05). After treatment, CP, HCT, FIB and PAR significantly decreased in both groups, with statistical significance (P <0.05) before and after treatment in the same group; and the reduction of these indexes in the treatment group was more obvious than that in the control group Significance (P <0.05). After treatment, the ABCD score in the treatment group was significantly lower than that in the control group, and the improvement was better than that in the control group. There was significant difference in ABCD score between the two groups (P <0.05). Conclusion Shuxuetong injection combined with cinepazide treatment of transient ischemic attack has a good clinical efficacy, which can effectively improve the relevant indicators of patients with hemorheology and reduce the risk of early onset of cerebral infarction, with a certain clinical application value.