论文部分内容阅读
目的探讨复杂型外阴阴道念珠菌病(VVC)的致病菌种和伊曲康唑、氟康唑治疗复杂型VVC的临床疗效。方法①将328例复杂型VVC患者,随机分为2组,即伊曲康唑组,口服200mg伊曲康唑,2次/d,共2d;氟康唑组,口服150mg氟康唑,顿服,3d后重复一次。两组同时使用400mg达克宁栓阴道给药,每晚1次,共7d。于治疗结束后第35d进行疗效评价。②于治疗前、随访时及治疗结束后,进行显微镜镜检和念珠菌培养。结果328例复杂型VVC患者中完成全部治疗和随诊的有227例,治愈192例,治愈率为84.6%;伊曲康唑组108例患者中治愈99例,治愈率为91.7%;氟康唑组119例患者中治愈93例,治愈率为78.2%。两组治愈率比较,伊曲康唑组优于氟康唑组,差异有统计学意义(P<0.05)。结论伊曲康唑对复杂型VVC的疗效优于氟康唑;白色念珠菌仍是复杂型VVC的优势菌群。
Objective To investigate the clinical efficacy of pathogens of complex vulvovaginal candidiasis (VVC) and itraconazole and fluconazole in the treatment of complex VVC. Methods ① 328 patients with complex VVC were randomly divided into two groups: itraconazole group, oral itraconazole 200mg, 2 times / d, a total of 2d; fluconazole group, oral 150mg fluconazole, Dayton Service, repeat after 3d. Two groups simultaneously use 400mg doxycycline vaginal administration, 1 night, a total of 7d. Efficacy was evaluated 35 days after treatment. ② before treatment, follow-up and after treatment, microscopic examination and Candida culture. Results Among 328 patients with complicated VVC, 227 patients were treated and followed up, 192 patients were cured and the cure rate was 84.6%. Among the 108 patients with itraconazole group, 99 patients were cured and the cure rate was 91.7%. Fluconazole Among the 119 patients in the azole group, 93 were cured, with a cure rate of 78.2%. The two groups of cure rate, itraconazole group was better than fluconazole group, the difference was statistically significant (P <0.05). Conclusion Itraconazole is superior to fluconazole in the treatment of complex VVC. Candida albicans is still the predominant group of complex VVC.