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十二指肠溃疡(DU)不管用何种药物(包括甲氰咪胍和雷尼替丁)治疗,1个月后均有约20%未能愈合,这种失败率较恒定,其原因可能有二:一为治疗方法不当;二为药效不够强。 Bardhan观察495人次DU发作者,4年中共发现66例甲氰咪胍(CD)1g/d治疗3个月未能愈合的难治性DU。经继续应用2或3倍的CD剂量治疗,但仅有56%治愈,余者治疗9.4个月仍未痊愈。CD无效的原因不明,患者一般溃疡较大,伴有较严重的十二指肠炎,年龄较轻而溃疡病史较长。CD的吸收是充分的,增加剂量并未能使对五肽胃泌素刺激胃酸的抑制有所
Duodenal ulceration (DU) About 20% of patients at 1 month after treatment did not heal with any of the drugs (including cimetidine and ranitidine), and the failure rate was relatively constant, possibly due to There are two: one for improper treatment; two is not strong enough. In a study of 495 DU patients, Bardhan observed 66 refractory DU patients who were treated with cidimetidine (CD) 1 g / d for 4 months and failed to heal for 3 months. After continued application of 2 or 3 times the CD dose, but only 56% were cured, the remaining 9.4 months of treatment has not yet recovered. The reason for the invalid CD is unknown, patients generally larger ulcers, associated with more severe duodenitis, younger and a longer history of ulcers. Absorption of CD is sufficient, and increasing doses did not result in inhibition of pentagastrin-stimulated gastric acid