目的观察氧化苦参碱对豚鼠哮喘气道炎症的影响。方法采用卵蛋白致敏后，再以卵蛋白雾化吸入诱发豚鼠哮喘发作。实验组在诱发豚鼠哮喘发作前１５ｍｉｎ，每只豚鼠腹腔内注射氧化苦参碱３０ｍｇ，两组豚鼠均每天诱发１次，共１０ｄ，然后应用生理盐水行支气管肺泡灌洗，收集灌洗液，离心后分别测定细胞总数、嗜酸性粒细胞、中性粒细胞等，同时取肺组织做病理检查。结果实验组各项检测指标均低于对照组，两组比较均有非常显著差异（Ｐ＜００１），病理检查所见，对照组豚鼠气管壁增厚，管腔狭窄，上皮脱落，粘膜下和支气管周围有以嗜酸性粒细胞为主的炎性细胞浸润，而实验组豚鼠上述病理改变明显减轻。结论氧化苦参碱对豚鼠哮喘气道炎症有明显改善作用。 Objective To observe the effect of oxymatrine on asthmatic airway inflammation in guinea pigs. Methods After sensitization with ovalbumin, guinea pig asthmatic attacks were induced by ovalbumin inhalation. In the experimental group, guinea pigs were intraperitoneally injected with 30 mg of oxymatrine 15 min before the onset of asthma in guinea pigs. The two groups of guinea pigs were induced once a day for 10 days. Bronchoalveolar lavage was performed with physiological saline and the lavage fluid was collected and centrifuged. After the determination of the total number of cells, eosinophils, neutrophils, etc., while taking lung tissue for pathological examination. RESULTS: The experimental group had lower detection indexes than the control group. There was a significant difference between the two groups (P<001). The pathological examination showed that the control group had thickening of the tracheal wall, narrow lumen, and epithelial shedding. Inflammatory infiltration of eosinophils was predominantly around the lower bronchus and bronchi, whereas the above-mentioned pathological changes of the guinea pigs in the experimental group were significantly reduced. Conclusion Oxymatrine can significantly improve asthmatic airway inflammation in guinea pigs.