论文部分内容阅读
目的:探讨冠心病患者同型半胱氨酸(Hcy)与超氧化物歧化酶(SOD)的关系。方法:采用高效液相色谱法测定50例冠心病患者(冠心病组)和37例健康体检者(正常对照组)空腹血浆Hcy的水平,根据测量结果将冠心病组患者分为高Hcy亚组(Hcy>15μmol/L)24例和正常Hcy亚组26例,黄嘌呤氧化酶法测定所有受检对象的血清SOD水平。结果:冠心病组血浆Hcy浓度明显高于正常对照组(P<0.01)。冠心病组患者的SOD水平明显低于正常对照组(P<0.01)。高Hcy亚组的SOD水平高于正常Hcy亚组(P<0.05)。结论:与正常对照组比较,冠心病患者血浆Hcy较高而SOD较低,提示高Hcy血症促进超氧化物的生成是其导致动脉粥样硬化的机制之一。
Objective: To investigate the relationship between homocysteine (Hcy) and superoxide dismutase (SOD) in patients with coronary heart disease. Methods: Fasting plasma Hcy levels were measured in 50 CHD patients and 37 healthy controls (normal control group) by high performance liquid chromatography (HPLC). According to the results, the patients with coronary heart disease were divided into high Hcy subgroup (Hcy> 15μmol / L) in 24 cases and normal Hcy subgroup in 26 cases. The levels of serum SOD in all subjects were determined by xanthine oxidase method. Results: Plasma homocysteine level in CHD group was significantly higher than that in control group (P <0.01). The level of SOD in patients with coronary heart disease was significantly lower than that in the normal control group (P <0.01). The SOD level in high Hcy subgroup was higher than that in normal Hcy subgroup (P <0.05). Conclusion: Compared with the normal control group, plasma Hcy and SOD in patients with coronary heart disease are higher, suggesting that hyperhomocysteinemia promotes the production of superoxide as one of the mechanisms leading to atherosclerosis.