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目的 :探讨病毒性肝炎 (ViralHepatitis ,VH)患者的心理状态、内分泌变化及与肝功能的关系。方法 :VH患者的结果与常模比较 ,心理测验同时检测血浆皮质醇 (Cortisol,CT)、血管紧张素Ⅱ (An -giotensinⅡ ,ATⅡ )及主要肝功指标 ,其结果与对照组比较。结果 :测定VH患者SAS、SDS得分、慢性肝炎(CH)组ScL - 90“躯体化、抑郁、焦虑、精神病性”及EPQ的“P、N”维度得分均明显高于常模且差异有显著性 (P <0 0 5或 0 0 0 1 )。VH病人急性期血浆ATⅡ、CT含量增高并与黄疸程度平行 (P <0 0 5或 0 0 1 )。ATⅡ含量与多项心理、肝功指标有相关性 (P <0 0 5- 0 0 0 1 )。结论 :CH病人的心理健康水平低下并具精神质及情绪不稳定的个性特征 ,是应予心理学手段干预的特殊群体。VH病人血浆CT和ATⅡ含量增高并与肝功能相关。ATⅡ水平与心理测验得分正相关 ,是有价值的心理应激激素指标之一
Objective: To investigate the relationship between psychological status, endocrine changes and liver function in patients with viral hepatitis (Viral Hepatitis, VH). Methods: The results of VH patients were compared with those of normotensive patients. Mental tests were performed to detect Cortisol (CT), angiotensin Ⅱ (AT Ⅱ) and main liver function indexes at the same time. The results were compared with the control group. Results: ScL - 90 “somatization, depression, anxiety, psychosis” and the “P, N” dimension of EPQ in SAS patients with SAS, SDS score and CH group were significantly higher than those of the normotensive group (P <0 0 5 or 0 0 0 1). The levels of plasma ATⅡ and CT in patients with acute exacerbation of VH were increased and paralleled those of jaundice (P <0.05 or 0.01). There was a correlation between ATⅡ level and multiple psychological and liver function indexes (P <0.05-0.001). Conclusion: CH patients with low mental health and personality characteristics of emotional and emotional instability, psychiatric intervention should be a special group. VH patients with elevated plasma CT and AT Ⅱ levels and liver function. AT Ⅱ level and psychological test scores are positively correlated, is one of the indicators of psychological stress hormone