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对７２名矽肺观察对象和５７名Ⅰ期矽肺患者分别用葡萄糖酸锌、亚硒酸钠和维生素Ｅ等抗氧化剂治疗前后的尿羟脯氨酸进行了测定。结果表明，矽肺观察对象和Ⅰ期矽肺患者治疗后尿羟脯氨酸有显著性降低（Ｐ＜０．０５～０．００１）。
Urinary hydroxyproline was measured in 72 silicotic patients and 57 stage I silicosis patients before and after treatment with antioxidants such as zinc gluconate, sodium selenite and vitamin E respectively. The results showed that urinary hydroxyproline significantly decreased after treatment in patients with silicosis and stage I silicosis (P <0.05 ~ 0.001).