作者分析了10例正常人和88例上消化道疾病患者胃粘膜-碳酸氢盐屏障功能,证实其在正常情况下有中和胃酸、减弱胃蛋白酶活性的作用。十二指肠球部溃疡患者中和指数和粘液保护指数明显低于正常,这可能是伴发胃部病变的一个原因。胃部疾病患者HCO_3~-和酸性粘蛋白减少是病变损伤上皮细胞的继发结 The authors analyzed the gastric mucosal-bicarbonate barrier function in 10 normal subjects and 88 patients with upper gastrointestinal disease, confirming their ability to neutralize gastric acid and impair pepsin activity under normal conditions. In patients with duodenal ulcer, the neutralization index and mucus protection index were significantly lower than normal, which may be one of the causes of gastric lesions. HCO 3 ~ - and mucins decrease in patients with gastric diseases are secondary to lesion-damaged epithelial cells