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本文主要综述了９０年以来有关肝血窦内皮细胞（ＨＳＥＣ）研究的新进展，包括ＨＳＥＣ的分离培养，细胞窗孔及其有关调节因素，第因子相关抗原的表达变化与肝纤维化的关系，分泌一氧化氮（ＮＯ）和内皮素（ＥＴ）及其对肝微循环调节和病理生理意义，细胞表面多种受体和粘附分子的表达与功能作用及其与肿瘤转移的相关性等。
This review summarizes the recent advances in the study of hepatic sinusoidal endothelial cells (HSECs) over the past 90 years, including the isolation and culture of HSECs, the relationship between the expression of cellular window and related regulatory factors, the expression of factor related antigens and hepatic fibrosis, Secretion of nitric oxide (NO) and endothelin (ET) and their regulation of hepatic microcirculation and its pathophysiological significance, the expression and function of multiple cell surface receptors and adhesion molecules and their correlation with tumor metastasis.