论文部分内容阅读
目的观察西洛他唑片联合阿司匹林片和氯吡格雷片对老年脑血管疾病神经介入后抗血栓作用的临床疗效及安全性。方法将39例进行脑血管疾病神经介入术患者随机分为对照组11例和试验组28例。对照组予以口服阿司匹林300 mg qd+口服氯吡格雷75 mg qd。试验组在对照组治疗的基础上,予以口服西洛他唑200 mg qd。2组患者均从术前1周服药至术后6个月。比较2组患者的临床疗效、血小板聚集率及血流动力学指标,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为85.71%(24/28例)和54.55%(6/11例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的血小板聚集率分别为(44.57±8.44)%,(56.83±11.46)%;全血黏度切变率分别为(2.92±1.09)%,(3.96±1.32)%;血浆黏度分别为(1.20±0.32),(1.51±0.43)m Pa·s;相对血液黏度切变率分别为(2.18±0.28)%,(2.50±0.41)%;血细胞比容分别为(0.38±0.06)%,(0.48±0.06)%;纤维蛋白原分别为(2.83±1.04),(3.29±1.26)g·L~(-1),差异均有统计学意义(P<0.05)。2组患者发生的药物不良反应以头痛和胃肠道反应为主,且试验组和对照组的药物不良反应发生率分别为21.43%和27.27%,差异无统计学意义(P>0.05)。结论西洛他唑片联合阿司匹林片和氯吡格雷片对老年脑血管疾病神经介入后抗血栓作用显著,且不增加药物不良反应的发生率。
Objective To observe the clinical efficacy and safety of cilostazol combined with aspirin and clopidogrel on the anti-thrombotic effects of neurotrauma after cerebrovascular disease in elderly patients. Methods Thirty-nine patients with neurological intervention for cerebrovascular disease were randomly divided into control group (n = 11) and experimental group (n = 28). The control group was given oral aspirin 300 mg qd + oral clopidogrel 75 mg qd. The experimental group in the control group based on the treatment, to be given cilostazol 200 mg qd. Patients in both groups took their medicine from one week before operation to 6 months after operation. The clinical efficacy, platelet aggregation rate, hemodynamic parameters and adverse drug reactions in two groups were compared. Results After treatment, the total effective rates of the experimental group and the control group were 85.71% (24/28 cases) and 54.55% (6/11 cases), respectively, with statistical significance (P <0.05). After treatment, the rate of platelet aggregation in test group and control group were (44.57 ± 8.44)% and (56.83 ± 11.46)%, respectively. The whole blood viscosity shear rates were (2.92 ± 1.09)% and (3.96 ± 1.32)%, respectively The plasma viscosities were (1.20 ± 0.32) and (1.51 ± 0.43) m Pa · s, respectively. The relative shear rates of blood viscosity were (2.18 ± 0.28)% and (2.50 ± 0.41)%, respectively 0.06)% and (0.48 ± 0.06)%, respectively. The levels of fibrinogen were (2.83 ± 1.04) and (3.29 ± 1.26) g · L -1, respectively, with statistical significance (P <0.05). Adverse drug reactions occurred in both groups were mainly headache and gastrointestinal reactions, and the incidences of adverse drug reactions in the two groups were 21.43% and 27.27%, respectively, with no significant difference (P> 0.05). Conclusion The combination of cilostazol and aspirin tablets and clopidogrel tablets has significant antithrombotic effect on the elderly patients with cerebrovascular diseases after neurological intervention, and does not increase the incidence of adverse drug reactions.