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目的:探讨肾源性腺瘤的临床病理特点、免疫组织化学特征及鉴别诊断。方法:回顾性分析1例输尿管肾源性腺瘤患者的临床资料:29岁男性,因肾积水入院,输尿管镜检查见一乳头状病变。对其进行光镜检查和免疫组织化学标记。结果:镜下见肿瘤由成团小管组成,被覆立方或扁平上皮细胞,部分呈“鞋钉”样,部分小管囊性扩张,间质慢性炎细胞浸润。免疫组织化学:PAX8、CK7、EMA、AMACR/P504S阳性表达,P63、P53、CD31、PSA、PSMA阴性表达,KI67增殖指数<2%。结论:肾源性腺瘤是一种易误诊的少见瘤样病变,确诊主要依靠组织病理学辅以免疫组织化学标记。
Objective: To investigate the clinicopathological features, immunohistochemical features and differential diagnosis of nephrogenic adenoma. Methods: A retrospective analysis of 1 case of ureteral adenomatous patients with clinical data: 29-year-old man, admitted to hospital due to hydronephrosis, ureteroscopy, see a papillary lesion. They were examined by light microscopy and immunohistochemistry. Results: Microscopically, the tumor was composed of small tubules and covered with cubic or flat epithelial cells. Some of them were “spiked” and some of them were cystic dilated and interstitial infiltrated with chronic inflammatory cells. Immunohistochemistry: PAX8, CK7, EMA, AMACR / P504S positive expression, P63, P53, CD31, PSA, PSMA negative expression, KI67 proliferation index <2%. Conclusion: Renal adenomatous adenoma is a kind of uncommon neoplasia easily misdiagnosed. The diagnosis depends mainly on histopathology with immunohistochemistry.