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目的探讨高强度聚焦超声(HIFU)联合超声造影剂治疗兔肝VX2肿瘤时,不同剂量的超声造影剂对治疗效应的影响。方法45只荷瘤兔随机分为三组:A组,单纯HIFU辐照组;B组和C组,均为联合辐照组,超声造影剂剂量分别为0.03 ml/kg和0.05 ml/kg。结果超声造影剂能够增强HIFU治疗效率,且超声造影剂的剂量越高,HIFU治疗效率提高越明显(P<0.05)。结论超声造影剂可以提高HIFU治疗效率,而且超声造影剂剂量越高则HIFU的治疗效率越高。
Objective To investigate the effect of different doses of ultrasound contrast agent on the therapeutic effect of high intensity focused ultrasound (HIFU) combined with ultrasound contrast agent in the treatment of rabbit liver VX2 tumors. Methods 45 tumor-bearing rabbits were randomly divided into three groups: group A, simple HIFU irradiation group, group B and group C, all of which were combined with irradiation group. The dose of ultrasound contrast agent was 0.03 ml / kg and 0.05 ml / kg, respectively. Results Ultrasound contrast agent can enhance the efficiency of HIFU treatment, and the higher the dose of ultrasound contrast agent, the more obvious the HIFU treatment efficiency (P <0.05). Conclusions Ultrasound contrast agent can improve the efficiency of HIFU treatment, and the higher the dose of ultrasound contrast agent, the higher the therapeutic efficiency of HIFU.