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目的探讨新生儿ABO溶血病早期诊断和治疗的效果。方法选择2001—2010年本院分娩新生儿中的ABO溶血病,密切监测患儿血清胆红素变化,在接近光疗标准时,及早给予光疗为主的综合治疗,监测和记录光疗过程中血清胆红素的动态变化、不良反应及预后。结果共纳入新生儿ABO溶血病512例(含早产儿78例),开始光疗时血清胆红素(176.1±42.2)μmol/L,患儿光疗后胆红素一般先上升,平均峰值(261.1±37.4)μmol/L,随之逐渐下降,全组按总疗程平均每日胆红素下降(22.1±12.2)μmol/L,平均光疗疗程(3.5±1.1)天。所有患儿全部治愈,无需要换血或发生核黄疸或死亡的病例。结论新生儿ABO溶血病通过早期诊断和早期光疗可以减少换血并防止核黄疸的发生。
Objective To investigate the effect of early diagnosis and treatment of neonatal ABO hemolytic disease. Methods ABO hemolytic disease in newborn infants born in our hospital from 2001 to 2010 was closely monitored. Serum bilirubin levels in children were monitored closely. When it was close to the standard of phototherapy, comprehensive treatment of phototherapy was given as early as possible. The serum bilirubin Dynamic changes, adverse reactions and prognosis. Results A total of 512 newborns with ABO hemolysis (including 78 preterm infants) were enrolled in this study. Serum bilirubin (176.1 ± 42.2) μmol / L at the beginning of phototherapy was used. The bilirubin level generally increased after phototherapy, with an average peak value of 261.1 ± 37.4) μmol / L, followed by a gradual decline. The mean daily bilirubin level decreased by 22.1 ± 12.2 μmol / L and the average duration of phototherapy (3.5 ± 1.1 days) in the whole treatment group. All children were cured, no need to change the blood or the occurrence of kernicterus or death. Conclusion neonatal ABO hemolytic disease through early diagnosis and early phototherapy can reduce the exchange of blood and prevent the occurrence of nuclear jaundice.