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目的 :脑外伤后常出现脑组织区域性缺血 ,为防治这种病理现象 ,通过局部应用山莨菪碱观察其对脑血流速度的影响。方法 :10只家兔采用额顶骨骨窗成形后硬脑膜外打击法制作动物模型 ,损伤性质为脑皮层挫裂伤。双侧硬脑膜外打击后形成双侧大脑半球脑皮层挫裂伤。设左半球为A侧 (对照侧 ) ,右半球为B侧 (治疗侧 )。致伤后应用局部微量等距离扩渗法分层浸注山莨菪碱稀释液于家兔右半球皮层 ,而左半球采用同样方法分层浸注等量盐水作为对照。分别于致伤前、后及每次局部用药前后行双侧大脑中动脉经颅多普勒 (TCD)超声和双侧皮层脑电图的动态检测。结果 :局部应用山莨菪碱后 15～ 3 0minB侧大脑中动脉血流速度为 ( 2 9 5± 2 9)cm/s,较用药前( 2 3 3± 2 9)cm/s明显升高 (P <0 0 5 ) ,且较A侧 ( 2 0 1± 2 9)cm/s亦显著升高 (P <0 0 5 )。每次用药后进行动态脑电图观察 ,未发现癫痫样脑电图发放。结论 :脑外伤后家兔脑血流速度下降 ,但脑皮层局部应用山莨菪碱后可增加脑血流速度 ,改善脑循环 ,且无异常脑电图出现
OBJECTIVE: Regional brain ischemia often occurs after traumatic brain injury. To prevent this pathological phenomenon, the effect of anisodamine on cerebral blood flow velocity was observed by local application. Methods: Ten rabbits were subjected to epidural bursting with frontal bone window to make an animal model of traumatic brain injury. Bilateral bilateral formation of cerebral hemisphere cerebral cortex contusion laceration after bilateral epidural. Set the left hemisphere to side A (control side) and the right hemisphere to side B (treatment side). After wounding, local microelement diffusion method was used to infiltrate anisodamine dilution in the right hemisphere of rabbits, and the same method was used to immerse the same volume of saline in the left hemisphere as control. The dynamic changes of bilateral cerebral middle cerebral artery by transcranial Doppler (TCD) and bilateral cortical EEG were performed before and after injury and before and after each administration. Results: The blood flow velocity of the middle cerebral artery in 15-3 min after topical application of anisodamine was (295 ± 29) cm / s, which was significantly higher than that before treatment (23.3 ± 29) cm / s P <0 05), which was significantly higher than that of A side (2 0 1 ± 2 9) cm / s (P 0 05). Dynamic electroencephalography after each medication, did not find epileptiform EEG distribution. Conclusion: The cerebral blood flow velocity of rabbits after traumatic brain injury is decreased. However, the application of anisodamine locally on cerebral cortex can increase the cerebral blood flow velocity, improve the cerebral circulation, and there is no abnormal EEG