论文部分内容阅读
目的探讨类风湿关节炎(RA)患者血清中同型半胱氨酸(Hcy)的水平及其在合并心血管病变(CVD)的RA患者血清中的变化。方法选取于2011年-2014年在河北省人民医院就诊的143例RA患者及143例健康体检者,根据患者是否患有心血管病变分为RA合并CVD组及RA未合并CVD组,用酶循环法法分别检测3组的Hcy水平,同时记录RA患者的病程、DAS28评分、C-反应蛋白(CRP)、类风湿因子(RF)、抗环瓜氨酸肽抗体(ACCP)、血沉(ESR)、血脂等相关指标,分析Hcy与各项指标之间的相关性。结果 RA患者血清Hcy水平明显高于健康体检者,差异具有统计学意义(P<0.05)。RA合并CVD患者血清Hcy水平明显高于RA未合并CVD患者,差异具有统计学意义(P<0.05)。相关性分析显示,RA患者血清Hcy水平与其关节肿痛数、ESR、LDL-C呈显著正相关(P<0.05)。结论 RA患者血清Hcy水平较健康体检者有所升高,并与心血管疾病的发展密切相关。
Objective To investigate the serum levels of homocysteine (Hcy) in patients with rheumatoid arthritis (RA) and their changes in sera of RA patients with cardiovascular disease (CVD). Methods A total of 143 RA patients and 143 healthy volunteers from Hebei Provincial People’s Hospital from 2011 to 2014 were selected and divided into RA-combined CVD group and RA-non-combined CVD group according to whether they had cardiovascular disease or not. Methods The levels of Hcy in 3 groups were detected and the course of disease, DAS28 score, C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (ACCP), erythrocyte sedimentation rate (ESR) Lipids and other related indicators, analysis of Hcy and the correlation between the indicators. Results The level of Hcy in RA patients was significantly higher than that in healthy controls (P <0.05). The level of Hcy in patients with RA complicated with CVD was significantly higher than that without RA (P <0.05). Correlation analysis showed that there was a significant positive correlation between serum Hcy levels and the number of joint swelling and pain, ESR and LDL-C in RA patients (P <0.05). Conclusions Serum Hcy level in RA patients is higher than that in healthy subjects and is closely related to the development of cardiovascular disease.